Therapeutic Use of Drugs

CADTH: Common Drug Review Database

https://www.cadth.ca/about-cadth/what-we-do/products-services/cdr
Through the Common Drug Review process, CADTH (Canadian Expert Drug Advisory Committee) conducts thorough and objective evaluations of the clinical, economic, and patient evidence on drugs, and uses this evaluation to provide reimbursement recommendations and advice to Canada’s federal, provincial, and territorial public drug plans, with the exception of Quebec.

ClinicalTrials.gov

http://clinicaltrials.gov/ct2/home
Change the first sentence to "A registry of study protocols for medical studies of human volunteers in the United States and worldwide. These studes can be currently enrolling, currently in process, or completed."

Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information

http://druginfo.nlm.nih.gov/drugportal/drugportal.jsp
This site is a true portal: search for a prescription, over-the-counter, herbal, or nutraceutical name and the site will provide links to additional information from a variety of United States-government-produced websites. Includes links to research articles, drug monographs, labels, and more. Can also be searched by drug category.

Drugs.com | Prescription Drugs - Information, Interactions & Side Effects

http://www.drugs.com/

This commercial site provides professional-level and consumer-level information on prescription drugs, over-the-counter medicines and natural products. Search or browse by drug name, drug class name, or conditions. Includes pill identifier, interactions checker, personal medication records and information in Spanish. Sources of information include American Hospital Formulary Service Drug Information (AHFS DI), United States Food and Drug Administration (FDA), Micromedex, and MedFacts.

Drugs@FDA
http://www.accessdata.fda.gov/scripts/cder/drugsatfda/
Browse or search for United States Food and Drug Administration (FDA) approved prescription and over-the-counter human drugs and therapeutic biologicals currently approved for sale in the United States. The site includes discontinued drugs and "Chemical Type 6" approvals. Contents for each drug include active ingredients; dosage form or route of administration; strength; marketing status; company that sponsored application for approval; FDA action date; and approval type. Many, but not all drug products have links to current FDA approved labels; older labels; approval letters; reviews; and patient information. In addition, new drug applications (NDA) and biologic license applications (BLA) can be listed.

Health Canada Drug Product Database (DPD)

http://www.hc-sc.gc.ca/dhp-mps/prodpharma/databasdon/index-eng.php

The Drug Product Database (DPD), a service from Health Canada, contains product-specific information on drugs approved for use in humans and veterinary applications in Canada. It contains approximately 15,000 products which companies have notified Health Canada as being marketed. Drug monographs provided by the manufacturers include information for professionals and consumers including Drug Statuses, Drug Identification Number (DIN), Company name, Strength, Therapeutic Classification (AHFS and ATC), scientific and pharmaceutical information, excipients, labels for the marketed product, etc. Search by drug name or active ingredient.

Institute for Safe Medication Practices

http://www.ismp.org/
This nonprofit seeks to educate consumers and health care providers on safe medication practices. For health care providers, under the section "Tools," it includes a list of drugs that should not be crushed, frequently-confused drug names, lists of Tall Man lettering, lists of high-alert drugs, and other sources of often difficult-to-find information about prescription drugs. The site also sells books, webinars, and other products, but access to the lists of drug information described in this abstract are all free.

ISPOR Scientific Presentations Database

http://www.ispor.org/research_study_digest/index.asp

This database, previously called ISPOR Outcomes Research Digest, includes almost 36,500 abstracts of research presentations and posters presented at International Society for Pharmacoeconomics and Outcomes Research (ISPOR) meetings across the globe from 1998 to the present. These abstracts are not routinely indexed elsewhere. Topics covered include clinical, economic and patient-reported outcomes, health policy, and methods & concepts. About half the entries include full PDFs of visual aids used in presentations. Search by disease/disorder, topic, or meeting name, or use a keyword search to search for drugs.

LiverTox

http://livertox.nlm.nih.gov/index.html
This site is co-run by the National Library of Medicine and the National Institute of Diabetes and Digestive and Kidney Diseases. Search or browse by name for herbals, supplements, and prescription or over-the-counter drugs. All entries provide overviews of the action of the active ingredient with special mention of the effects on the hepatic system, information on products containing the active ingredient, chemical formula and structures, and links to canned searches of PubMed, Clinicaltrials.gov, and TOXLINE, as well as citations to articles, package inserts, and other high-quality information about the drug, herbal preparation, or supplement. Some entries also include case reports of liver damage. Useful list of appendixes in left column, including Clinical Course, Phenotypes, Classes of Drugs, etc. 

Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations

http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm
This resource is produced by the United States Food and Drug Administration. The electronic version of this resource offers information for medical providers on generic drug substitution for brand products or therapeutic drug equivalence. It also has information on whether specific drugs are currently protected by patents. Searching can be completed by active ingredient, proprietary name, patent, applicant holder, or application number. The electronic version is updated daily. The PDF printable version (under the Publications link) has an Annual edition and a Current Cumulative Supplement edition that can also be used. Pharmacists in community practice, drug informationists, and pharmaceutical research companies would be the primary users of this resource.

PubMed Central

http://www.ncbi.nlm.nih.gov/pmc/

By law, all NIH-funded investigators must deposit an electronic version of their final, peer-reviewed manuscripts into PubMed Central (PMC) to be made publicly accessible no later than 12 months after publication. PubMed Central is the repository of biomedical and life sciences articles which include topics on therapeutic use of drugs, pharmacogenomics, drug selection, development, analysis, and economic aspects. Search by keyword, MeSH (Medical Subject Heading) term or author to locate full-text research articles.